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KMID : 0363020050350040907
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Journal of Korean Academy of Periodontology
2005 Volume.35 No. 4 p.907 ~ p.919
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Prevalence of fimA Genotypes of Porphyromonas gingivalis Strains in peri-implant sulcus
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서동건
권영혁/박준봉/허익/정종혁
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Abstract
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Porphyromonas gingivalis is a gram negative, black-pigmented anaerobe, associated with
periodontitis & peri-implantitis. Fimbriae(fimA) of P. gingivalis are filamentous components on
the cell surface and important in the colonization and invasion of periodontal tissue. But all P.
gnigivalis strains don't have equal pathogenicity, inequality among strains originates fromdifferent fimA genotype. P. gnigivalis fimA gene encoding fimbrillin(structural subunit of fimbriae)
has been classified into 5 genotypes(typesⅠ to Ⅴ) based on the nucleotide sequences. In the
present study, we examined the prevalence of these fimA genotypes in patients with dental
implant and the relationship between prevalence of these genotypes and a condition of
peri-implant tissue. Dental plaque specimens obtained from 189 peri-implant sulci of 97
patients with dental implants were analyzed by 16S rRNA fimA gene-directed PCR assay.
P. gingivalis were detected in 86.2% of the alll samples. Among the P. gingivalis-positive
samples, a significant difference in the occurrence of typeⅡ was observed between test and the
two control groups. In two control groups, typeⅡ fimA were detected in 6.3%(PD<5㎜/BOP-),
18.7%(PD<5㎜/BOP+). In the test group(PD?5㎜/BOP+), typeⅡ fimA genotype were detected most
frequently in 50.0% . And a correlation between specific fimA types and peri-implantitis was
found in typeⅡ(R
2=1.105).
These results suggest that P. gingivalis strains that possess typeⅡ fimA are gradually
increased, as a condition of peri-implant tissue is getting complicated and are closely associated
with peri-implant health status. We speculate that these organisms be involved in periimplantitis2)
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KEYWORD
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FimA genotypes Porphyromonas gingivalis Peri-implant sulcus
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